New Articles Alert: Aging Cell, Vol. 25, No. 11, November 2026

Depletion of TOP2A accelerates MSC senescence and disrupts heterochromatin integrity. TOP2A directly regulates LMNB1 expression to maintain MSC nuclear integrity and epigenomic stability. Overexpression of TOP2A counteracts MSC senescence through Lamin B1-mediated chromatin reorganization and epigenomic stabilization. Pharmacological inhibition of TOP2A triggers premature brain aging and neurodegenerative-like behavioral phenotypes in mice.

Dietary EGCG intake was associated with slower biological aging, lower mortality risk, and longer residual life expectancy in humans. Mechanistic studies in C. elegans and AML12 hepatocytes support peroxisome biogenesis and peroxisomal fatty acid β-oxidation as key contributors to EGCG-related longevity and anti-senescent effects.