Weekly Newsletter
November 2, 2026
WEEKLY NEWSLETTER
November 2, 2026
NEWS
C-BRAIN partners with NVIDIA to scale open-source AI and speed discoveries in AD. ARPA-H grant will support training an AI model on spatial proteomics from human brains.
Pared down from six to four goals, the updated plan moves AD risk reduction and speeding the impact of scientific discoveries to the top of the list.
Scanning the brains of adult mice reveals a mosaic of more than 500 distinct zones, each with its own lipid signature.
Exploration activated compensatory neuronal circuits that counteracted the harmful effects of p-tau on attention and memory.
In worms, cold temps amped up production of the metabolite dihydrobiopterin. Neurons generated more tyrosine, and it juiced proteostasis.
In mice, dialing down the cholesterol transporter ABCA1 curbed dopaminergic neuron loss and improved motor function.
COMMENTS
With NVIDIA On Board, C-BRAIN’s AI Models Get a Boost
Luca Foschini
Bart De Strooper
P. Murali Doraiswamy
Hello Lipizone, Unit of 3D Lipid Map of Mouse Brain
Rik van der Kant
Martin Giera
Laura Beth McIntire
Priyanka Narayan
Anil Cashikar
Edoardo Marcora
Curiosity Keeps Mouse Memory Keen—A Mechanism for Cognitive Reserve?
Yaakov Stern
Jackson Bittencourt
Michael Ewers
Bruno Conti on Chilly Conditions Rev Up Metabolic Response, Prevent Protein Aggregates
Cholesterol Overload: A Driver of Neurodegeneration in Parkinson’s?
Hanseok Ko
Joel Blanchard
Jens Pahnke
Iliya Lefterov and Radosveta Koldamova
Lei Cao
Ana García-Osta on A Phospholipase to Stave Off Age-Related Synapse Loss?
Tuberin Loss Angers Astrocytes, Rapamycin Appeases Them
Andy Liu
Francisco Quintana
Lotta Granholm
Jean-Pierre Brion
Luca Foschini
Bart De Strooper
P. Murali Doraiswamy
Hello Lipizone, Unit of 3D Lipid Map of Mouse Brain
Rik van der Kant
Martin Giera
Laura Beth McIntire
Priyanka Narayan
Anil Cashikar
Edoardo Marcora
Curiosity Keeps Mouse Memory Keen—A Mechanism for Cognitive Reserve?
Yaakov Stern
Jackson Bittencourt
Michael Ewers
Bruno Conti on Chilly Conditions Rev Up Metabolic Response, Prevent Protein Aggregates
Cholesterol Overload: A Driver of Neurodegeneration in Parkinson’s?
Hanseok Ko
Joel Blanchard
Jens Pahnke
Iliya Lefterov and Radosveta Koldamova
Lei Cao
Ana García-Osta on A Phospholipase to Stave Off Age-Related Synapse Loss?
Tuberin Loss Angers Astrocytes, Rapamycin Appeases Them
Andy Liu
Francisco Quintana
Lotta Granholm
Jean-Pierre Brion
CONFERENCE CALENDAR
25th Annual MCI Symposium
2 April 2027
Gordon Research Conference: Molecular Mechanisms to Human Translation in Parkinson's Disease
09 – 14 May 2027
The Venusberg Meeting on Neuroinflammation - 9th
13 – 15 May 2027
Interventions in Aging Conference - 6th
16 – 19 May 2027
2 April 2027
Gordon Research Conference: Molecular Mechanisms to Human Translation in Parkinson's Disease
09 – 14 May 2027
The Venusberg Meeting on Neuroinflammation - 9th
13 – 15 May 2027
Interventions in Aging Conference - 6th
16 – 19 May 2027
JOBS
T32 Post-Doctoral Position, Geriatric Psychiatry
Columbia University Medical Center
New York, New York
PET Imaging Researcher
Icahn School of Medicine at Mount Sinai
New York, New York
Columbia University Medical Center
New York, New York
PET Imaging Researcher
Icahn School of Medicine at Mount Sinai
New York, New York
GRANTS
AFAR Grants for Junior Faculty and Glenn Foundation for Medical Research (GFMR) Grants for Junior Faculty
The Artificial Intelligence and Technology Collaboratories (AITC) Annual National Research Award Competition (AITC-ARA-27-001)
The Artificial Intelligence and Technology Collaboratories (AITC) Annual National Research Award Competition (AITC-ARA-27-001)
PAPERS OF THE WEEK
Visit Papers of the Week to browse or download the latest PubMed citations related to the study of Alzheimer's and other neurodegenerative diseases.
View Recommended Papers selected by our editors, scientific advisory board and readers. We urge Alzforum members to submit comments or recommended papers. Thank you for your willingness to share your ideas openly and promote critical thinking and creativity in AD research.
View Recommended Papers selected by our editors, scientific advisory board and readers. We urge Alzforum members to submit comments or recommended papers. Thank you for your willingness to share your ideas openly and promote critical thinking and creativity in AD research.
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